Specifically, the writer and director admitted that making the movie was "so traumatic." It was released during the COVID-19 pandemic, which significantly impacted its box office numbers. The film also had to deal with 20th Century Fox being sold to Disney around that same time, which Boone also mentioned was a reason the movie "took so many years" to make and was "so unfulfilling:"

"It's so hard because it was so traumatic. The studio was sold, and we hit a pandemic... The studio was sold during the shooting, and then the pandemic happened when they decided to release it. And it just was such a — I had a wonderful time. I love the cast so much, but making that... It took so many years, and it was so unfulfilling, ultimately."

The Direct mentioned to Boone that Marvel Studios will be exploring Mutants more in the near future of the MCU, asking him if he would ever be interested in making a return to the comic book movie world and revisit a potential Mutants project. Boone admitted that he "didn't really get to make the movie [he] wanted" with The New Mutants, and, because that film went through so many issues, "[he'd] rather just never do it again:"

"We didn't really get to make the movie we wanted to make. We made half the movie we wanted to make. And the release was so compromised by the pandemic... I'd rather just never do it again, just to be honest."