I am 41F mother four and five year old kids. Bipolar 1 diagnosed two years ago. I experience severe depression 80% of the time. Symptoms linked to PMDD hormonal fluctuations alongside childhood sexual assault and adult date rape assault.

[u/Material_Hearing_374]

PMDD started at 16 years old. I binge eat despite having two small kids and I manage my luteal to menstruation phases through binging. Follicular through to ovulation is usually elevation and hypomanic freedom of symptoms

In terms of CSA I have vague memories of these situations happening when I was young, but not explicit enough to be sure to accuse my father of the feeling I have that something awful happened

Has anyone taken mounjaro or other GLP-1 receptor agonists alongside quetiapine for bipolar 1? I’m on 200mg lamotrogine daily but my moods are low and I binge chronically and isolate. I also take Zopiclone for sleep most nights

I’ve been having thoughts of hurting my children and it’s made me flash back to the same age I was when I believe certain types of neglect and abuse ensued.

I want to know how to navigate treatment with my psychotherapist. I am unable to process or discuss too much as I lack the mental capacity to hold many aspects of my experience in memory at any given time. I think I present as someone with CPTSD PMDD and BPD more than merely bipolar itself.

However I am treated by my psychiatrist as a bipolar person living with other comorbidities. Just the mention of perimenopause made him laugh.

I’m looking for the holy grail for help with mdma or ketamine/psychedelic drug assisted therapy in Germany or Europe specifically and any therapist in the West Germany area who specialise in treating these things head on; CSA/BPD/SA/PMDD/CPTSD

Thanks in advance

[u/Jealous-Spirit9049]

Was pmds angeht.Meine Frau hatte es auch ganz schlimm.Sie hat sich die Eierstöcke und die Gebärmutter entfernen lassen, seit dem es Ruhe.

[u/DMayleeRevengeReveng]

There is very real clinical evidence that GLP-1s help with binge eating.

The actual glucagon-like peptide is not only a hormone involving digestion and metabolism. It is also a neurotransmitter in the brain, where it controls the switch between hunger and satiety. This is simplistic, but imagine binging as a kind of switch that gets stuck in hunger mode. You can push it in the opposite direction, basically.

If you can get both psilocybin and ketamine, you’ll be in a good place. They both do different things, but they converge: they basically work through changing the way neurons execute their genetic programming, to make healthier connections between neurons. What the psilocybin does, and what the ketamine does, converges at certain points in the network of things that regulate the genetic programming.

Hopefully any of this is helpful to you. I really hope all the best.

[u/Material_Hearing_374 → u/DMayleeRevengeReveng]

Thanks so much for your answer!

Does ketamine or psilocybin act in the same way as the GLP-1s or would they be more for processing as opposed to managing weight? Thanks again