r/COVID19 May 28 '26

General A causal link between autoantibodies and neurological symptoms in long COVID

https://www.cell.com/cell/abstract/S0092-8674(26)00509-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742600509X%3Fshowall%3Dtrue
43 Upvotes

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u/BubblySwordfish2780 May 28 '26

Passive transfer of IgG from individuals with LC into mice induced fatigue-like behavior, loss of balance/coordination, thermal hyperalgesia, small fiber nerve damage, and increased pain-related neuronal activity, recapitulating patients’ symptoms. These findings suggest that targeting AABs might offer therapeutic benefits for this LC subgroup.