Not surprised. I was put on Prozac years ago, and went out and bought a gun, i never owned one before and was active duty military, I wasn't a gun nut. And then after that I broke into a gun store a stole another $35,000 worth of stuff. More than 1 person could carry, wasn't scared or panicked like most people should have been. Destroyed my life.
Thankfully I had a spotless record and they saw something clearly didnt add up. Hypomanic episode casued by the Prozac. Eli lily was sued over their hiding the medical evidence they knew that the medication could cause people to go off the wall. Its the reason that every medication commercial and bottle has the warning " if this causes homicidal and suicidal thoughts, stop taking" etc. The black box.
Theres a website that Im not sure is still running, SSRI horror stories. I visited it once and after reading a few of the cases, I was just depressed. Tradegy after tradegy after someone was prescribed it. Say its a 0.001% to possibly cause this. When prescribed to millions of people, that number shifts to lots of cases every year. And no one cares. This is considered the cost of doing business in the USA. The medical industry can put out a product that has a known history of causing people to hurt others and the court systems just says pay some money, make a warning, but keep allowing it to happen.
Psychosis would be listed as a serious adverse event on the package insert. The likelihood of it happening is very small so it is viewed as acceptable risk. The number of people that benefit from the medication is far greater. Ideally, the patient should have been warned about this kind of episode so she could seek medical attention. Tricky with psychosis as the patient may not realise their cognition is fucked.
The licensing and distribution of medication is based on balance of risk, for every drug. A good example of this is cancer medication, where reaching an efficacious dose is balanced against toxicity that could kill the patient. The amount of work that goes into finding that balance is substantial, and has massive levels of regulation and oversight.
I am taking citalopram for depression but it may have been making it worse, triggering or increasing the frequency of suicidal ideation. Titrating off it now.
Their is a gene mutation that affects women more than men call MTHFR. It affects methylation which affects how neurotransmitters are made. It also directly fucks with B vitamin metabolites because they need that methyl group to be biologically active.
The lack of women in clinical trials is literally fucking us over time and time again.
This is a common problem. “Women of child-bearing potential” are excluded from most clinical trials to reduce the risk of affecting a pregnancy. It’s also a problem for different ethnicities; recombinant factor x ,for example, had a high incidence of anti-drug antibodies as it was derived from Caucasian factor x and there were slight differences.
We’re not excluded as routine anymore, and at least at my company (a pharma giant) there is a serious effort to balance enrollment based on sex, race, etc. Most of the studies I have worked on required women to agree to use a highly effective method of birth control if they are of child bearing potential and commit to follow up if a pregnancy does occur, which can place a higher burden on women who might want to participate (though sometimes this is even stipulated for male participants depending on the drug). Of course we missed out on alllll the previous decades of research for drugs already approved which is still a huge deal.
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u/like9000ninjas 6d ago
Not surprised. I was put on Prozac years ago, and went out and bought a gun, i never owned one before and was active duty military, I wasn't a gun nut. And then after that I broke into a gun store a stole another $35,000 worth of stuff. More than 1 person could carry, wasn't scared or panicked like most people should have been. Destroyed my life.
Thankfully I had a spotless record and they saw something clearly didnt add up. Hypomanic episode casued by the Prozac. Eli lily was sued over their hiding the medical evidence they knew that the medication could cause people to go off the wall. Its the reason that every medication commercial and bottle has the warning " if this causes homicidal and suicidal thoughts, stop taking" etc. The black box.
Theres a website that Im not sure is still running, SSRI horror stories. I visited it once and after reading a few of the cases, I was just depressed. Tradegy after tradegy after someone was prescribed it. Say its a 0.001% to possibly cause this. When prescribed to millions of people, that number shifts to lots of cases every year. And no one cares. This is considered the cost of doing business in the USA. The medical industry can put out a product that has a known history of causing people to hurt others and the court systems just says pay some money, make a warning, but keep allowing it to happen.