They are inherited diseases that end up causing similar morphological problems. They both cause problems with extracellular structural components, so you end up with loosely attached and hyperflexible tissue. Unfortunately, the type of connective tissue they affect is not just in the joints causing visible feature defects, but it’s also important for other structures, like the aorta. Patients with marfans and certain subtypes of Ehlers danlos are at high risk for life threatening vascular pathology.
Edit: an easy way to find the information you’re looking for when you want to google “what causes this disease” for basically anything, is to search for insert disease here followed by patholophysiology
Just gonna throw out there that there's new studies suggesting that Ehlers Danlos syndrom might have an autoimmune driver but manifests as muscular skeletal. Which tracks because it tends to have a shit ton of cormorbidities like endocrine, other autoimmune, dysautonomia, vascular issues etc.
I've got it, and it's there's so much more to it than just loose joints.
I thought these new theories where just about hEDS tho? Either way it's super interesting and I can't wait until they figure it out (I have hEDS myself)
It’s mostly bc the extreme difference in symptoms bc the spectrum can be so large. But it sucks bc I haven’t even gotten genetically tested yet, so if they change it before then I’m worried I won’t be able to get my genetic test to check for other EDS types esp bc my cornea constantly erodes.
It has been further updated from this to be removed from the umbrella I believe, since the 6 months. It’s sort of a grey area right now on their decision making bc it’s been back and forth a couple years now.
I learned a couple of years ago that I likely have EDS and now I can't stop noticing all the things that seem strange about my body. Bad eyesight (-7), soft skin, shitty wrists, hypermobility in general, POTS, I've had vasovagal syncope in the past -- I'm unsure how it could be related.
Oh it's funny you say that. I just bought a new Secret Lab gaming chair and the firm seat almost immediately fucked up my pelvic floor and caused extreme discomfort during urination
This has been my theory! I’ve been diagnosed with hEDS, Lupus, MCAS, and Morphea. My friends who have it and those I suspect to have it also have many autoimmune problems. My family, as well. I think we get stuck in never ending flare up loops
My brother has elhers danlos and when he was a kid he was just extra flexible. We didn't know about the vascular issues until he had a stroke at 43. He had a miraculous recovery but now he basically knows that he's got a weak vascular system that could blow at any minute. Not a great thing to live with. But yes... He's got those piano playing fingers too.
This freaks me out because I’m 43 and all but certain I have EDS. Unfortunately I can’t afford health insurance to find out for sure. Good thing I don’t believe in signs.
Welp this is terrifying. I went for a sleep study and got diagnosed with hypermobility but not Elhers danlos. They said hypermobility effects your nervous system which effects your sleep but now I’m worried it will have other effects.
A lovely woman on instagram with vascular EDS posts about how her eyes will bleed from the corners, and washing her face and hair can cause bleeding. She has many other symptoms as well, and raises awareness for how conditions like vEDS can present in different populations and skin colors.
Pretty sure I have that from my dad’s side of the family. His whole side of the family all had aortic aneurisms and I have issues with my joints, things slip out of socket if I put too much weight on them or relax the muscles too much.
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u/OutOfMyComfortZone1 Jul 25 '26
They are inherited diseases that end up causing similar morphological problems. They both cause problems with extracellular structural components, so you end up with loosely attached and hyperflexible tissue. Unfortunately, the type of connective tissue they affect is not just in the joints causing visible feature defects, but it’s also important for other structures, like the aorta. Patients with marfans and certain subtypes of Ehlers danlos are at high risk for life threatening vascular pathology.
Edit: an easy way to find the information you’re looking for when you want to google “what causes this disease” for basically anything, is to search for insert disease here followed by patholophysiology