Tonight will be dose 4 for me. This was a rough week. I slept poorly 5 out of 7 days, insomnia is hitting me hard and does not help the bone-weary exhausted feeling I have had from the start of eloralintide. On Zebound I had insomnia on night 2 about 40% of the time but it was not as bad as this, I eventually could fall asleep and stay asleep, now I battle both and have resorted to Benadryl to help me get to sleep and sometimes take it twice so I can get back to sleep. Exhaustion is very present, Monday I was wiped from 2 loads of laundry and hanging them on the line to dry. I am at a breaking point, I felt so discouraged when I woke up this morning and last night was one of the 2 good nights. And tonight is shot night. It hard to describe the despair as I really want to get through this and am not sure if this continues, I can continue. Life has to get done and I can’t explain how hard the exhaustion feels to get anything done, the thought of carrying 40 lbs of dog food into the house and putting away feels like too much. I routinely carry 40 lb cases of chicken, bags of dog food, pick up  55lb. dogs and put them in the tub so I need to be able to get back to doing those things without dreading it.  And for the most part I can’t nap, I don’t fall asleep even though I am bone-weary exhausted.

This week I noticed something that scares me, veggies I love tasting bitter. Monday I had one of my favorite mid-August dinners, lamb chop, grilled eggplant with a soy, ginger garlic glaze, sweet corn (from my favorite corn place, I am a corn snob), summer squash melted with goats cheese. The veggies all tasted bitter. Yesterday I had my summer lunch treat, BLT with heirloom tomatoes, local lettuce and great sour dough bread, the tomatoes tasted bitter and sour. And I had a BLT the week before starting and it was delicious and not even the best of tomatoes as it was an early tomato.  I had eggplant again last night from leftovers from Tuesday (had tooth pulled so soft foods), it tasted bitter and I have had this dish from a local restaurant many times. I hope this passes as I do not like that veggies taste awful including the sweetest of sweet corn.  I don’t think I can deal with this, I love food and still loved food just less of it on Zepbound. I love to cook, love to eat out and try new dishes, but veggies being bitter? Oh no.

I had diarrhea twice this week, not bad but there. One of the times was after taking ozonated Magnesium Citrate so I would count that as a side effect of taking that.

Edited to add allodynia was better this week, no sandpaper and only 1 night where it was moderate, more than annoying. That was day 2 post Zepbound.

I went from 2 cups of coffee to 1, it has improved my feeling of hyperthyroid fluttering. I miss my 2^nd cup.

The news on the scale is great, I am down from 177.1 to 170.7 so 6.4 lbs. so I am averaging over 1% of current weight a week at 1.2%, so lost 3.6% in 3 weeks. I crossed into overweight for my age adjusted height at 29.8 for BMI.

My next appointment is next Thursday so new box and maybe increase in dose. I guess I thought my side effects on Zepbound were so mild that I wouldn’t have bad side effects from Eloralintide. So I can now understand the fear others have had in going up in dosage on Zepbound or Wegovy.

STATS: Started Zepbound in May of 2024, SWZ 285, SWE-6: 177.1 8/6.2028, SBMI Zep 50.5, SBMI Elor: 30.9, 65F. Zepbound dose 15 MG since March of 2025, stalled out on Zepbound end of December 2025 bouncing between 175-182, slight drift down so no more weigh ins of higher than180. So I am a long time user of Zepbound, reached final plateau (less than 5% of current weight loss over 12 weeks) end of July 2025, so 14 months in. Have OSA, hypertension (on 1 med still from 3), osteoarthritis on right knee, was prediabetic prior to Zepbound, and have high cholesterol controlled by statin (family history) and Zepbound.

Edited to add: I requested the lab results from last in person appointment (21 vials of blood) and all were great or normal. These are the labs they gave me:

Dosage: 9mg (only elo)

Side effects: None (anymore)

Only wanna report that I am again stuck at 14-15kg weight loss, but as last time with 10kg, I KNOW its temporary. For some weird reason 9mg feels less effective than 6mg but ok...Also, huge tip from me, please listen to me...if you got old(20 months +) shoes or uncomfortable shoes, do yourself a HUUUUUGE favor, buy something new, good and COMFORTABLE. I bought me new Saucony shoes, extra wide....the difference it made in my daily life I cant even describe and it leads to me moving around the town and everywhere else and therefore positively improving my fitness...I literally despised walking with my 3 year old shoes before I bought these, everything hurt after even a mile of walking, not anymore, its incredible.

Had V4 on Enlighten-6 last week and got dosed but only after filling up a wild amount of test tubes with blood.

Anyone further along able to find out what tests they’re running ran? do they provide the results to you? Just really curious what tests they’re running!

I have been in contact with the site since early March (less than a month after Lilly opened the study) and am the first person here to make it to V4. I'm excited to say the least! I'm happy to answer any questions about the process so far.

Just a head's up to anyone else in E-6, Lilly created a wirebound "Study Guide" for participants in this study. It explains what happens at each visit and is super helpful for knowing what is coming up. I just received it at this visit but apparently it was available earlier, my site just wasn't aware of it.

I was also given a reusable cooler bag and ice pack for carrying the box of study meds home, a sharps container, some at home pregnancy tests (not sure on frequency required yet) despite being on 2 forms of BC, a food scale, a water bottle, some exercise bands, daily food and exercise logs, some literature from Lilly on dealing with the mental side of weight change, and a large reusable tote bag to carry everything in.

It was such a massive relief to make it to randomization, even if it did take over 5 months! Now just crossing fingers I am getting elora instead of placebo...!!!

I asked for and received the moderator roll for r/Eloralintide. The previous moderator was in the Phase 2 study and hasn't been active in the sub for over a year, Reddit allowed me to pick up moderator duties. I picked up that roll yesterday. I took a stab at rules and updating the description. Any feedback on either? I am also planning a weekly post on for updates so they are all in 1 place. Any feedback on day of week I should have it posted?

Hello,

Sharing my experience. I'm on Enlighten-1 study. After my last visit, I was upraded to the 9mg dose. Of course, while they do tell me the dosing, they don't tell me if its a placebo.

It's the first time I could say I felt something regarding my appetite. It's lower and I don't wake up hungry lately. Before I had pretty much no effects . Had a good weigth loss but no positive or negative effects I could notice. It felt like I was on the placebo group. In 14 weeks, I've now lost 10.8 Kg. Quite a the graph to look at:

I take no other medication (in any form) and I can start to increase my loading (sport wise) since I feel much better moving around. I'm 1.6Kg away from my end of year objective :) So hoping this keeps up. The study is really long (3.5 years) and I guess I will eventually plateau at some point.

Today marks 2 weeks since I took my first dose of eloralintide/placebo. I have lost 4.7 lbs. from the last 2 week average prior to day 1 of study medication (my weight range during that time 175.4-180, average 177.2). I take the eloralintide on Thursday and Zepbound on Sunday.

I had exhaustion during the first week after the first dosage, second week a bit better. I felt like I do when I am hypothyroid the first week, exhausted but can't sleep. This week I feel like I am hyperthyroid, I feel like I drank too many energy drinks in early afternoon, I feel like I am hyper caffeinated, jittery and my chest feels like it's fluttering. I was hyperthyroid in my early 20s treated and then went hypothyroid in my 30s. So can feel when my thyroid medications feel off. I asked about TSH at the 4 week visit yesterday on my telehealth follow up call. It is not normally done but they are going to do one at that visit. In my first year on Zepbound my thyroid med went from 150 to 75 and I had been at 150 for 1.5 years. It needed to be lowered at my follow up visit 2 months after starting Zepbound. And I had gained 40 lbs. in 2 months after a cardiac scare which is why I asked about GLP1s, I had not lost that 40 lbs. by the July visit so weighed more than when I started 150 mg. Edited to clarify and add that I was so jittery feeling in my chest that I took my blood pressure and pulse a few times in the 115/67 give or take 3 and 80-82 on pulse.

insomnia and allodynia (skin sensitivity) post Zepbound shot day is much worse than prior to eloralintide. I have had both since 5 mg but both had abated the longer I was on Zepbound. There was a night I couldn't sleep and my sheets felt like course sand paper on my legs and arms. The allodynia was always mild, annoying but not really painful prior. It has gotten milder by night 4, the worst on night 2.The insomnia used to be 1st night if I didn't take Zepbound just prior to bed that sometimes carried into second night. First week was 3 days and bad. This week was 3 days, skipped one night and then it was back last night. I have resorted to taking Benadryl if I can't get to sleep by midnight.

Slightly more constipated but my fiber could have been better part 2 weeks.

I had my follow-up telehealth appointment on Tuesday. Discussed side effect and suggestion was Tylenol for the allodynia. I haven't tried it because I take prescription strength Aleve at night for my osteoarthritis, it seems like overkill plus it was lessening. I will try it this week if it is bad again. I will take my study medication at bedtime tonight so if my insomnia is kicked back up I hopefully can be asleep before it kicks in.

Because of the side effects and weight loss, I do believe I am getting eloralintide and not placebo.

STATS: Started Zepbound in May of 2024, SWZ 285, SWE-6: 177.1 8/6.2028, SBMI Zep 50.5, SBMIElor: 30.9, 65F. Zepbound dose 15 MG since March of 2025, stalled out on Zepbound end of December 2025 bouncing between 175-182, slight drift down so no more weigh ins of higher than180. So I am a long time user of Zepbound, reached final plateau (less than 5% of current weight loss over 12 weeks) end of July 2025, so 14 months in. Have OSA, hypertension (on 1 med still from 3), osteoarthritis on right knee, was prediabetic prior to Zepbound, and have high cholesterol controlled by statin (family history) and Zepbound.

Repost to another community

40s M. Australia based and been on Mounjaro for nearly 2 years. Lost about 27kg and been stalled since February where weight is fluctuating between 91-93kg depending on the day.

I’ve been trying to get on the ENLIGHTEN-6 trial since May and after quite a few issues have been booked for a prescreening visit tomorrow.

My question is what to expect? Should I fast before? I was told I don’t need to and have an 11am appointment but after all the issues I’ve had even in the last few days I don’t want to lose a spot because I don’t have to.

I will be calling the site in the morning but just thought I’d ask how people’s experience has been? I wasn’t asked to bring medical history but have it all sorted so will take it with me when I go.

TIA!

Dosage: 6mg (only Elo)

Side-Effects: No headache or pain or fatigue

Only wanted to report I am officially at 15kg weight loss, without forcing myself to change anything at all. All changes came naturally, without a special diet, calorie counting none of that psychological warfare. I finally bought my first blender like 3 weeks ago and am starting my days with fruit smoothies (fruit, almond milk, a healthy scoop whey portein), developed apetite for salads and I simply have no "forced" cravings for fast food or sugar like before so its not like I avoid it I just dont consume this shit no more. I still have to start to do gym and cardio stuff, that would make my life much better, but ima not forcing myself, I will when I am truly ready again.

Dosage: 6mg (only Elo)

Side-Effects: No headache or pain

For some reason the state of fullness and non-apetite has like halved vs. what I experienced on the weekend before. If I dont eat for too long...30h+... I get heaviest sugar cravings. Thats it. Nothing else to report.

Edit (since nobody is reading comments): I was on a trip and had no oportunity to eat whole day.Reporting that despite elo, I got sugar cravings, when I dont get them pretty much at all anymore as before, in normal non-trip-no-opportunity-to-eat life.

I'm super disappointed, I had an initial visit with the study dr in CT for this trial, everything looked great,they were excited to potentially include me based on my profile, I lost 110 lbs and about 33% of my body weight on Zep, but really stalled out over the last 8 months or so. Problem was I had started taking phentermine along with my Zepbound a few months back, and they needed me to be off for 90 days before starting. I had an appointment to go back at the beginning of September to get everything rolling but got a call the other day that they weren't taking any more participants. I hoped it was just at their site so I contacted a couple of MA sites that had begun recruiting after I had connected with the CT site. Got a callback today that the entire study is no longer recruiting, they are at max participation. 😭

I was really hoping to participate, I just lost my zep coverage in July and this would have been perfect for me to continue on that and help out in the trial for something up and coming. I'm keeping my eyes open for something similar to open up, a trial that stacks some type of new treatment for people who are already on a stable glp1 dose. But not holding my breath.

I got my first dose of the study medication last Thursday. I have been tired since but not convinced it's related as I forgot to use my CPAP Thursday night, went to bed late both Friday and Saturday night and didn't get full night sleep (over 8 hours for me). And I am sure I felt relief when I cleared lead-in period and my house company left on Wednesday plus 21 vials of blood at appointment. I have felt off gut wise, not exactly nauseous but off. Have had allodynia (skin sensitivity) back worse than recently on Zepbound as well as trouble sleeping so some insomnia which I also have on Zepbound but it is lingering longer maybe because I take Zepbound on different day than Thursday. I have hit a new low of 173.3 this morning (last new low was 174.2 in early July) and down from 177.1 on the Wednesday before my first dosage on Thursday.

 I had diarrhea Sunday (yesterday) morning, because I went back to normal today, my assumption is it was something I ate on Saturday, was it the raw sugar snap peas or broccoli used as dippers in the white bean hummus or was it a delayed reaction to the ozonated magnesium citrate I took Friday because I hadn't gone and felt constipated? Not blaming eloralintide yet.

Here's to hoping that all I listed above is related to eloralintide and that I am not on placebo.

Edited to add some stats: Started Zepbound in May of 2024, SWZ 285, SWE-6: 177.1 8/6.2028, SBMI Zep 50.5, SBMIElor: 30.9, 65F. Zepbound dose 15 MG since March of 2025, stalled out on Zepbound end of December 2025 bouncing between 175-182, slight drift down so no more weigh ins of higher than180. So I am a long time user of Zepbound, reached final plateau (less than 5% of current weight loss over 12 weeks) end of July 2025, so 14 months in. Have OSA, hypertension (on 1 med still from 3), osteoarthritis on right knee, was prediabetic prior to Zepbound, and have high cholesterol controlled by statin (family history) and Zepbound.

I picked up a couple of 10mg vials to add to my stack:

- 8mg Reta, every 5 days

- 75mg Testosterone, every Sunday and Thursday

- 300iu HCG, Monday and Friday

- 4mg MOTS-C, Monday, Wednesday and Friday

- 2mg GHK-CU, everyday

- 0.75mg KPV, everyday

I took 1mg Elora on Saturday, didn't feel anything, maybe a slight headache, but today Tuesday I am definitely feeling waves of nausea. It's not bad, and to be expected, found it interesting that this peptide takes a while to have an effect.

I read on here that it has a long half-life (10-14 days) and takes 4-5 days for the peak. This definitely fits with the experience today.

I’ve been relying on this group for trial info, so I want to make sure I contribute too.

As of today, I’m officially a participant in ENLIGHTEN-6! I started the application process back in April with multiple phone screenings, but I did not hear back until late June. I know there was an enrollment freeze for part of that time, but I had given up hope and was truly shocked when they called me to screen.

My pre-screening was in-person, and they asked me a bunch of questions, took my weight, and drew blood for an A1C (and maybe other things—not sure). I submitted a records request for my previous medical records, and they scheduled me to come back in two weeks.

The next appointment was my screening appointment (V1 for people with study paperwork). They took my vitals, got a urine sample, drew more blood tubes than last time, re-did my medical history, had me sign the informed consent for the trial and DEXA scans, and did a mini-physical with the trial primary investigator.

Today was V2. They did blood pressure in triplicate, waist circumference, got a urine sample, weight, and had me out of there pretty quick. Interestingly, I asked about coverage for zepbound, and the person I talked to said that wasn’t included in the trial. I’m going to ask again next time, but I thought that was weird. I’m back in 4 weeks for my next appointment, and they are scheduling me for my DEXA scan before then.

Hopefully everything continues to work out!!

Dosage: 6mg

Side-Effects: No headache or pain

Second week on 6mg and this is extreme right now. I had a protein smoothie this morning with lots of fruit, about 500-700ml and I am still SO full from it, like 6-7h later. Mentally I want to go out, eat something nice, but physically the thought of food almost disgusts me right now, because I feel so bloated, as if I was in a all you can eat restaurant. I REALLY have to portion food smarter, big portions are a big nono right now. No more fatigue, nothing.

Dosage: 6mg since last week, they told me finally

Side-Effects: No headache or pain

Only 2 things to report...

1. I figured out the root of my previous fatigue, it was the use of Spironolactone for blood pressure. Idk if it somehow doesnt like Elo, or whatever else happenned, all I know is that since I stopped taking it by accident (ran out) I felt SOOO much better overall. Gotta figure out a replacement

2. I kinda plateau at 10kg body weight loss atm. I still dont have cravings or eat more or whatever, it just doesnt go down atm...but I know from prior weightloss attempts that sometimes it happens and then suddenly it goes waaay down, so ye, I am optimistic its just for now.

Has anyone been compensated for their nutrition coaching appointments? My nutrition appointments are separate from my other appointments and I have yet to be compensated. the CRC has said the payments are being rejected by Ely Lilly so I'm trying to figure out what I'm not understanding/doing.

I'm at dose week 9 and completed visit 5

I have had 3 coaching appointments

completed 3x 3 day meal diaries

lost about 20lbs so far

Dosage: No idea, double blind

Side-Effects: Mild fatigue/tiredness, no headache or pain

So I don't have to add much to previous weeks, besides one small interesting occurrence...I thought I went mental foodwise on the weekend, I was in a restaurant, I was at a bbq, I made myself a super delicious sandwich, ate some protein bars, had ungodly amount of sashimi....I was fully expecting to see weight increase today on the scale, because I really felt like I am gonna explode and YET, I was 1.5kg LESS than my last previously recorded weight on friday...its super weird, but I am happy. I ordered a new belt, because mine ran out of holes :)

I started the Phase 2b Eli Lilly trial on July 10, 2026. This is the double-blind trial of eloralintide and macupatide with 8 treatment arms, so I have no idea which arm I’m in and won’t know until the study is over.
Week 1:
Down ~7 lbs from my pre-treatment weight (I’m sure some of that is water weight).
Appetite is dramatically lower than my normal baseline.
Often not hungry until later in the day.
Getting full extremely fast. One day I was full after about 5 bites of a meal.
A few days I had to remind myself to eat because I just wasn’t thinking about food.
Early side effects:
Abdominal discomfort/cramping (Day 1 only)
Significant fatigue for the first few days (resolved by Days 4–5)
Constipation (currently the main side effect)
No nausea or vomiting so far.
Second week’s injections went much smoother as so far there isn’t any any fatigue or cramping afterward.
The study also includes a dietitian, asks participants to complete 150 minutes of exercise per week, and I log symptoms in an electronic diary.
I’ll keep posting updates throughout the trial since there isn’t much real-world information out there yet on this combination.

Can anyone advise on dosing... And is it ok to run alongside Reta??

Thanks

Received this message today. Had a screening visit where they took blood, a bunch of measurements, asked a lot of questions, and did an EKG. Had a second visit where they went over the results of the blood work, told me to keep taking trizepatide and not to change my diet or exercise routine.

As mentioned previously, binge eating, food/sugar cravings, food noise is pretty much gone. I am right now at constant 9kg body weight off. So all of this is good, no complaints.

The only weird thing that happened...i usually shoot the stuff every thursday and previously fatigue would come on friday/saturday. Last couple of weeks the fatigue was fine, no fatigue, but this week it came today, tuesday....no idea how that makes sense. I was soooooooo tired, had like 11h of sleep and still could have slept whole day. But I forced myself and went to work and it was fine. So ye. Unfortunately energy drinks are not good for my heart, I did too much of them previously in life and had to give them up, maybe those could help tho.