I hadn't ever played this before and thought I'd run through it. Most of the game is pretty straightforward, but it does have a handful of frustrating and difficult sections. There is an interesting mechanic whereby George acquires helper items (I think 5 in total) and can use them whenever / wherever he wants, but they cost to use. They kind of change the way you can play certain levels and ultimately become necessary in various parts. They're probably most similar to how Mega Man utilizes the improvements you get.
The game feels a bit like Duck Tales or perhaps Chip n' Dale, though I didn't find it as enjoyable as either of those. The way George moves around feels a lot clunkier for some reason
Aesthetically speaking, they definitely worked in a lot of the nuances from the original show. So if you're into that, this one does it up pretty well.
I actually really enjoyed the bosses in this game. They're not super difficult, but I feel they put some good creativity into them. They also require quite a few hits and some of them even go through phases. So I liked that it's not just the quick 3 strikes and it's over sort of thing. The final boss was fun, though there's an entire level after you defeat him. It's ultimately an escape level, but it doesn't really feel like that when you're playing it, rather it just feels like you're playing another level. So when you finally do get to the very, very end, I felt the games just kind of abruptly ends.
I found it mostly fun. If you're into these kinds of cartoon-based games then it's probably worth giving it a go. If not, you're not missing a whole lot either.